The book is presented as a timeline of development with emphasis on human and vertebrate biology. Fully documented examples exhaustively illustrate general principles in viewing development of structure and function as an integrated unity. All chapters have been extensively revised by noted international specialists. The book incorporates the most recent studies and research, including advances in stem cells and genomics. New chapters on aging and glial biology have been added. Continuity with previous editions is maintained by retention of the historical perspective for which this title is known. The book stresses the universal aspects of the development of the nervous system in both vertebrates and invertebrates, especially at the cellular level, but also compares and contrasts different levels of neuronal organization, giving much attention to phylogenetic and individual variations in neuronal ontogeny. With its comprehensive and completely updated coverage, generous illustrations, and a table of contents that reads like a Who's Who in neuroscience, this new and expanded Fourth Edition is a must have book for the professional neurobiologist and others seeking definitive and authoritative information in this important field. Instructors, as well as graduate and advanced under-graduate students, will also appreciate its clearly presented information, historical references, and organization for classroom use.