This book presents an in-depth review of the state of the art of cyber-physical systems (CPS) and their applications. Relevant case studies are also provided, to help the reader to master the interdisciplinary material. Features: includes self-test exercises in each chapter, together with a glossary; offers a variety of teaching support materials at an associated website, including a comprehensive set of slides and lecture videos; presents a brief overview of the study of systems, and embedded computing systems, before defining CPS; introduces the concepts of the Internet of Things, and ubiquitous (or pervasive) computing; reviews the design challenges of CPS, and their impact on systems and software engineering; describes the ideas behind Industry 4.0 and the revolutions in digital manufacturing, including smart and agile manufacturing, as well as cybersecurity in manufacturing; considers the social impact of the changes in skills required by the globalized, digital work environment of the future.